F ANCA antigens and dsDNA enhances the ability of NETs to induce autoantibody formation and furthers cell damage101. ANCA-induced NETs generated by C5aprimed neutrophils could lead to enhanced thrombosis and inflammation in AAV by promoting the expression of tissue factor, a protein required for coagulation94,95. NETs can also present PR3 and MPO to dendritic cells102. These dendritic cells intern