Studies evaluatingOns to the statistical methods used in this study.Studies evaluating the efficacy of directly administered antiretroviral therapy (DAART) for the treatment of HIV-infected individuals have yielded mixed results. A systematic review and meta-analysis of randomized trials by Ford and colleagues found no evidence overall for DAART benefit [1]. However, both the Ford anal
A and adjusting for differences based on sex, we no longer see this correlation. In addition, in this study, HCV coinfection is not associated with loss of elite controller status. Taken together, this suggests that HCV coinfection does not directly affect HIV replication dynamics or natural history, but that it may act synergistically with HIV to produce a greater number of associated complicatio
Ing administration of rifabutin 300 mg once daily (Treatment A, #) or rifabutin 300 mg once daily plus SQV-SGC 1200 mg three times daily (Treatment C, ).treatment was greater (33 ) compared to when coadministered with saquinavir (21 ). The within patient variability was approximately 29 .Effects of rifabutin on saquinavirpharmacokineticsThe mean ( CV) AUC(0,8 h), Cmax and C8 for saquinavir when a
Ing administration of rifabutin 300 mg once daily (Treatment A, #) or rifabutin 300 mg once daily plus SQV-SGC 1200 mg three times daily (Treatment C, ).treatment was greater (33 ) compared to when coadministered with saquinavir (21 ). The within patient variability was approximately 29 .Effects of rifabutin on saquinavirpharmacokineticsThe mean ( CV) AUC(0,8 h), Cmax and C8 for saquinavir when a
Ine for drug testing. Plasma was stored at a central repository for resistance testing. We monitored adherence with electronic pill bottle monitors (MEMS 6 TrackCap, AARDEX Group, Ltd., Sion, Switzerland) for the first 2 months after subjects started antiretroviral therapy (ART). We selected a single medication for monitoring according to the following hierarchy: dosed most frequently, combination
Nt populations [6,7]. Opioid treatment programs (OTPs) provide a potential framework for DAART because patients visit multiple times each week to receive opioid agonist medication. Moreover, maintenance treatment at OTPs permits prolonged DAART, which is difficult in models based on outreach workers. Based on promisingDirectly Administered Therapy for HIVFigure 1. Study screening, enrollment, and
Es would most likely not have been affected. The measures of immune activation were not assessed at enrollment into the study cohort, and we therefore cannot make temporal inferences of a causal nature nor could we control for them in the multivariable Cox models. We used prevalence rate ratios (PRRs) to estimate the associations of interest as risk was our parameter of interest. We chose PRRs as
Nt populations [6,7]. Opioid treatment programs (OTPs) provide a potential framework for DAART because patients visit multiple times each week to receive opioid agonist medication. Moreover, maintenance treatment at OTPs permits prolonged DAART, which is difficult in models based on outreach workers. Based on promisingDirectly Administered Therapy for HIVFigure 1. Study screening, enrollment, and