The previous 2011 Malawian guidelines, we estimated that 80.0 (95 CI 77.6 to 82.3) of the HIV-positive population was in need of ART at the time of the survey (Table 2). The WHO 2013 ART guidelines, which were implemented in 2014 in Malawi (raising the CD4 threshold from 350 to 500 CD4 cells/mL), increased eligibility to 87.5 (95 CI 85.5 to 89.4) and decreased ART coverage from 80.5 (77.8 to

Ain lesions without Ab deposits. They include multiple sclerosis plaques [111] as well as lesions of adrenoleukodystrophy, DRPLA, and ischemic strokes [115]. Ab was also shown to induce CD40 expression by cultured microglia [116,117] and cultured vascular endothelial cells [116,118][118-120]. HIV-1 induces the latter phenomenon as well [121] It may be the mechanism by which CD40 expression is up-r

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