R JS, Kietz S, Wimalasena J, Gustafsson JA: Estrogen receptor beta inhibits 17beta-estradiol-stimulated proliferation of the breast cancer cell line T47D. Proc Natl Acad Sci USA 2004, 101:1566-1571. 2. Liu MM, Albanese C, Anderson CM, Hilty K, Webb P, Uht RM, Price RH Jr, Pestell RG, Kushner PJ: Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression. J Biol Chem 2002, 27

Ltivariable analyses, increasing levels of DC-SCRIPT were associated with good prognosis only for pT1 (small tumor without lymphatic/vascular invasion) tumors and not for larger tumors. These and additional exploratory Cox univariate analyses are summarized in Table 3. The prognostic value of DC-SCRIPT is visualized in KaplanMeier curves (Figure 1) as a dichotomized variable in these biologically

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Test for trends. The Cox proportional hazards regression model was used to control for multiple factors simultaneously and to estimate adjusted hazard ratios (HRs) and 95 confidence intervals. The relative increase in the risk of breast cancer recurrence for each of the three higher quartiles was estimated in comparison to that for the lowest quartile; it was also used to test for a linear trend

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Lpropane-1,3-diamine. Acknowledgements We especially thank the patients and surgeons, pathologists, and internists for their assistance in collecting tumor tissues and patients' clinical follow-up data. We thank Joan Bolt, Marion Meijer, Mieke Timmermans, Anita Trapman, and Wendy van der Smissen for their excellent technical support. This work was financially supported by VICI grant 918-66-615 (aw