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Quency at baseline (medians of 43 and 134 observed doses in those reporting to the OTP,5 days and 5 days per week, respectively). Fifty six percent (IQR 20 ?9 ) of expected observed doses were actually observed. Drop-out from the OTP or ART discontinuation accounted for a substantial proportion of non-observed doses. For example, when considering only the weeks in which DAART participants were re

Istically significant period effect was found (P values i0.52). The primary statistical analysis gave an estimate of the reduction in saquinavir exposure when coadministered with rifabutin, as measured by AUC(0,8 h) and Cmax(0,8 h) of 47 (95 CI 30, 60 ) and 39 (95 CI 11, 59 ), respectively. Figure 1 illustrates the plasma concentrationtime profiles for saquinavir when administered alone (Treat

Es would most likely not have been affected. The measures of immune activation were not assessed at enrollment into the study cohort, and we therefore cannot make temporal inferences of a causal nature nor could we control for them in the multivariable Cox models. We used prevalence rate ratios (PRRs) to estimate the associations of interest as risk was our parameter of interest. We chose PRRs as